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USA MAX Drug - Rx List - SAFE MED CARES Articles

What is Viagra?


Viagra is the trade name for a drug called Sildenafil. Viagra is one of a class of drugs known as PDE-5 (Phosphodiesterase type 5) inhibitors. Viagra and the other PDE-5 inhibitors can help men with erectile dysfunction (male impotence) by enhancing the erectile response when a man is sexually stimulated. Aside from Viagra, the other drugs in this class are Cialis (Tadalafil) and Levitra (Vardenafil).

Viagra does not cause a man to be sexually aroused. Viagra is only effective if you are sexually aroused. To understand how it works you need to understand the mechanics of how a man gets an erection. When you get sexually stimulated, the nervous system in the erectile tissue of your penis releases nitric oxide (NO). The nitric oxide stimulates an enzyme that produces something called a messenger cyclic guanosine monophosphate (cGMP). The cGMP relaxes the smooth muscle cells. One result of this is that the arteries in your penis dilate and the blood can flow into your penis more easily. Another result is that the erectile tissue itself fills with blood. Both of these process result in an erection. Viagra works by maintaining the level of cGMP in the smooth muscle cells. If you are not turned on, your brain will not stimulate the release of any nitric oxide and you will not produce any cGMP.

What is Sildenafil ?


Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7.

VIAGRA is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.

How does Sildenafil work ?


Erectile dysfunction (sometimes called impotence) means that you cannot get or maintain a proper erection. There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis.

Sildenafil works by preventing the action of a chemical in the body called phosphodiesterase type 5. This helps to relax (widen) blood vessels and improves the flow of blood. In erectile dysfunction, sildenafil improves the blood flow to the penis following sexual stimulation, and this helps to maintain an erection.

Sildenafil is available on prescription but it is only prescribed on the NHS under certain circumstances. Do not take it if you do not have erectile dysfunction.

Another brand of sildenafil tablets called Revatio® is used in a completely different condition called pulmonary arterial hypertension. This is a specialist treatment and no information about this brand of sildenafil is included in this medicine leaflet.

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